Same Old Challenges in Subgroup Analysis-Should We Do More About Methods Implementation?

Schandelmaier, Stefan and Guyatt, Gordon (2024) Same Old Challenges in Subgroup Analysis-Should We Do More About Methods Implementation? JAMA network open, 7 (3). No. e243339. ISSN 2574-3805

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Abstract

Sherry et al considered the methodological quality of subgroup analyses reported in 379 oncology trials. The authors explored a number of fundamental problems with these analyses: in forest plots, use of linear rather than logarithmic scales and failure to present overall pooled estimates; failure to conduct and highlight tests of interaction; and readiness to make unwarranted inferences regarding the credibility of postulated subgroup effects. They reported a distressingly high frequency of each of these problems.

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