Items where Author is "Lehotzky, Attila"

Oláh, Judit and Szénási, Tibor and Lehotzky, Attila and Norris, Victor and Ovádi, Judit (2022) Challenges in Discovering Drugs That Target the Protein–Protein Interactions of Disordered Proteins. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (3). ISSN 1661-6596

Oláh, Judit and Lehotzky, Attila and Szénási, Tibor and Ovádi, Judit (2021) Anti-aggregative effect of the antioxidant dj-1 on the tppp/p25-derived pathological associations of alpha-synuclein. CELLS, 10 (11). ISSN 2073-4409

Lehotzky, Attila and Oláh, Judit and Fekete, János Tibor and Szénási, Tibor and Szabó, Edit Zsuzsanna and Győrffy, Balázs and Várady, György and Ovádi, Judit (2021) Co-Transmission of Alpha-Synuclein and TPPP/p25 Inhibits Their Proteolytic Degradation in Human Cell Models. FRONTIERS IN MOLECULAR BIOSCIENCES, 8. ISSN 2296-889X

Oláh, Judit and Lehotzky, Attila and Szénási, Tibor and Ovádi, Judit (2021) A potential innovative therapy for Parkinson’s disease: Selective destruction of the pathological assemblies of alpha-synuclein. In: Dementia in Parkinson's Disease. IntechOpen Ltd, London. ISBN 9781839688447

Schiedel, Matthias and Lehotzky, Attila and Szunyogh, Sándor and Oláh, Judit and Hammelmann, Sören and Wössner, Nathalie and Ovádi, Judit (2020) HaloTag-Targeted Sirtuin-Rearranging Ligand (SirReal) for the Development of Proteolysis-Targeting Chimeras (PROTACs) against the Lysine Deacetylase Sirtuin 2 (Sirt2). CHEMBIOCHEM. pp. 1-7. ISSN 1439-4227 (print); 1439-7633 (online)

Oláh, Judit and Lehotzky, Attila and Szunyogh, Sándor and Szénási, Tibor and Orosz, Ferenc and Ovádi, Judit (2020) Microtubule-Associated Proteins with Regulatory Functions by Day and Pathological Potency at Night. CELLS, 9 (2). pp. 1-21. ISSN 2073-4409

Oláh, Judit and Szunyogh, Sándor and Szaniszló, Tamás and Szénási, Tibor and Szabó, Adél and Lehotzky, Attila and Berki, Tímea and Nyitray, László and Ovádi, Judit (2019) Interactions between two regulatory proteins of microtubule dynamics, HDAC6, TPPP/p25, and the hub protein, DYNLL/LC8. BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR CELL RESEARCH, 1866 (12). ISSN 0167-4889

Schiedel, Matthias and Herp, Daniel and Hammelmann, Sören and Swyter, Sören and Lehotzky, Attila and Robaa, Dina and Oláh, Judit and Ovádi, Judit and Sippl, Wolfgang and Jung, Manfred (2018) Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). JOURNAL OF MEDICINAL CHEMISTRY, 61 (2). pp. 482-491. ISSN 0022-2623

Swyter, Sören and Schiedel, Matthias and Monaldi, Daria and Szunyogh, Sándor and Lehotzky, Attila and Ovádi, Judit (2018) New chemical tools for probing activity and inhibition of the NAD+ -dependent lysine deacylase sirtuin 2. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 373 (1748). pp. 1-13. ISSN 0962-8436

Szénási, Tibor and Oláh, Judit and Szabó, Adél and Szunyogh, Sándor and Láng, András and Perczel, András and Lehotzky, Attila and Uversky, Vladimir N. and Ovádi, Judit (2017) Challenging drug target for Parkinson's disease: pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1863. pp. 310-323. ISSN 0925-4439

Szabó, Adél and Oláh, Judit and Szunyogh, Sándor and Lehotzky, Attila and Szénási, Tibor and Csaplár, Marianna and Lőw, Péter and Ovádi, Judit (2017) Modulation of microtubule acetylation by the interplay of TPPP/p25, SIRT2 and new anticancer agents with anti-SIRT2 potency. SCIENTIFIC REPORTS, 7 (1). pp. 1-14. ISSN 2045-2322

Schiedel, M. and Rumpf, T. and Karaman, B. and Lehotzky, Attila and Oláh, Judit and Ovádi, Judit (2016) Aminothiazoles as potent and selective Sirt2 inhibitors – a structure-activity relationship study. Journal of Medicinal Chemistry, 59 (4). pp. 1599-1612. ISSN 0022-2623

Zwick, V. and Nurisso, A. and Simões-Pires, C. and Bouchet, S. and Martinet, N. and Lehotzky, Attila and Ovádi, Judit (2016) Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 26 (1). pp. 154-159. ISSN 0960-894X

Schiedel, M. and Rumpf, T. and Karaman, B. and Lehotzky, Attila and Gerhardt, S. and Ovádi, Judit (2016) Structure-based development of an affinity probe for sirtuin 2. ANGEWANDTE CHEMIE INTERNATIONAL EDITION, 55 (6). pp. 2252-2256. ISSN 1433-7851

Rumpf, T. and Schiedel, M. and Karaman, B. and Roessler, C. and North, B. J. and Lehotzky, Attila and Oláh, Judit and Ovádi, Judit (2015) Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. NATURE COMMUNICATIONS, 6. p. 6263. ISSN 2041-1723

Lehotzky, Attila and Oláh, Judit and Szunyogh, Sándor and Berki, Tímea and Ovádi, Judit and Szabó, Adél (2015) Zinc-induced structural changes of the disordered TPPP/p25 inhibits its degradation by the proteasome. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1852 (1). pp. 83-91. ISSN 0925-4439

Tökési, Natália and Oláh, Judit and Hlavanda, Emma and Szunyogh, Sándor and Szabó, Adél and Babos, Fruzsina and Magyar, Anna and Lehotzky, Attila and Vass, Elemér and Ovádi, Judit (2014) Identification of motives mediating alternative functions of the neomorphic moonlighting TPPP/p25. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1842 (4). pp. 547-557. ISSN 0925-4439

Oláh, Judit and Tőkési, Natália and Lehotzky, Attila and Orosz, Ferenc and Ovádi, Judit (2013) Moonlighting microtubule associated proteins: Physiological functions by day and pathological functions at night. CYTOSKELETON. pp. 1-9. ISSN 1949-3584

Ovádi, Judit and Horváth, István and Hudecz, Ferenc and Kovács, János and Lehotzky, Attila and Oláh, Judit and Orosz, Ferenc (2008) p25, egy új agyi fehérje szerkezete és funkciója = Structure and function of a new brain-specific protein, p25. Project Report. OTKA.