Szeitner, Zsuzsanna and Doleschall, Anna and Varga, Marina and Keltai, Katalin and Révész, Katalin and Gyurcsányi, Ervin Róbert and Mészáros, Tamás (2017) Spiegelmers as potential receptors for cTnI diagnostics. Analytical Methods, 9. pp. 5091-5093. ISSN 1759-9679
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Official URL: http://pubs.rsc.org/en/content/articlelanding/2017...
Abstract
We demonstrate the first application of a nuclease resistant aptamer, the so-called Spiegelmer, in a sandwich-type affinity assay by quantitative assessment of cardiac Troponin I (cTnI) in blood serum samples. To this end, we used a bead-based homogenous proximity assay (AlphaLISA) in which luminescence is generated by the Spiegelmer and antibody-modified donor and acceptor beads brought into proximity by their binding to cTnI.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science / természettudomány > Q1 Science (General) / természettudomány általában Q Science / természettudomány > QD Chemistry / kémia Q Science / természettudomány > QD Chemistry / kémia > QD01 Analytical chemistry / analitikai kémia Q Science / természettudomány > QR Microbiology / mikrobiológia > QR180 Immunology / immunológia |
| Depositing User: | Berényi Szilvia |
| Date Deposited: | 22 Feb 2018 11:07 |
| Last Modified: | 22 Feb 2018 11:07 |
| URI: | http://real.mtak.hu/id/eprint/74906 |
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