Szeitner, Zsuzsanna and Lautner, Gergely and Nagy, K. Szilvia and Gyurcsányi, Ervin Róbert and Mészáros, Tamás (2014) A rational approach for generating cardiac troponin I selective Spiegelmers. Chemical Communications (50). pp. 6801-6804.
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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2014...
Abstract
We report the first protein selective Spiegelmers of diagnostic relevance by rational identification of a target epitope and reverse screening of Spiegelmer candidates following the selection procedure. Application of the presented approach resulted in isolation of cardiac troponin I selective Spiegelmers with low nanomolar dissociation constant and functionality in serum.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science / természettudomány > Q1 Science (General) / természettudomány általában Q Science / természettudomány > QD Chemistry / kémia Q Science / természettudomány > QD Chemistry / kémia > QD01 Analytical chemistry / analitikai kémia Q Science / természettudomány > QR Microbiology / mikrobiológia > QR180 Immunology / immunológia |
| Depositing User: | Berényi Szilvia |
| Date Deposited: | 12 Feb 2015 07:35 |
| Last Modified: | 03 Apr 2023 08:25 |
| URI: | http://real.mtak.hu/id/eprint/21583 |
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